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Targets Recommended: IL Receptor Interleukin

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11634	IL-15-IN-1	IL Receptor; Interleukin	Immunology/Inflammation
	IL-15-IN-1是一种 IL-15依赖性细胞的选择性抑制剂(IC50:0.8 μM)。
T76892	Ordesekimab AMG 714,PRV-015	IL Receptor	Immunology/Inflammation
	Ordesekimab (AMG 714) 是一种人 IgG1κ 抗 IL-15 (Interleukin Related) 单克隆抗体。Ordesekimab 竞争性与 IL-15 结合，会抑制 IL-15 与 IL-2Rβ 和 IL-15 受体复合物的共同 γ 链的相互作用，却不与 IL-15Rα 链发生反应。Ordesekimab 可用于研究无反应性乳糜泻 (NRCD) 。
T11673	IRAK4-IN-4	IRAK; cGAS	Immunology/Inflammation; NF-κB
	IRAK4-IN-4 （化合物 15）是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶，IC50为 2.1 nM。
T73014	NLRP3-IN-15
	NLRP3-IN-15 是一种有效的、选择性的 NLRP3炎症小体抑制剂 (KD: 5.87 μM)。NLRP3-IN-15 抑制 IL-1β 释放，IC50为 0.131 μM。NLRP3-IN-15可用于炎症研究。
T62950	IRAK4-IN-18
	IRAK4-IN-18 是一种白介素 1 受体相关激酶 4 (IRAK4) 的有效抑制剂 (IC50: 15 nM)。IRAK4-IN-18 能够抑制 THP 和 DC 细胞中 LPS 诱导的 IL23 产生，阻断关节炎模型大鼠的关节炎发展。IRAK4-IN-18 可用于研究关节炎疾病。

化合物

IL-15-IN-1

Cat.No: T11634

Synonym:

Target: IL Receptor, Interleukin

Ordesekimab

Cat.No: T76892

Synonym: AMG 714,PRV-015

Target: IL Receptor

IRAK4-IN-4

Cat.No: T11673

Synonym:

Target: IRAK, cGAS

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04632	IL-15 Protein, Human, Recombinant 白细胞介素,IL-15,白介素,interleukin 15	Human	E. coli
	IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.
TMPJ-00154	IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells) sIL-15 receptor subunit α,Il15ra,Inter...	Mouse	HEK293 Cells
	Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il...
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α,IL15...	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPJ-01461	IL-15RA & IL-15 Protein, Human, Recombinant (hFc) IL-15 Receptor α & IL-15 Fusion Protein,	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ...
TMPJ-01462	IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc) IL15,IL15RA&IL15,IL-15,<...	Human	HEK293 Cells
	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ...
TMPY-04049	IL-15 Protein, Human, Recombinant (His) interleukin 15,白细胞介素,白介素,IL-15	Human	E. coli
	IL-15 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P40933-1.
TMPY-06587	IL-15RA Protein, Human, Recombinant (His) interleukin 15 receptor, alpha,interle...	Human	E. coli
	IL-15RA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.22 kDa and the accession number is NP_002180.1.
TMPY-06634	IL-15RA Protein, Human, Recombinant (hFc & Avi), Biotinylated CD215,interleukin 15 receptor, α,...	Human	HEK293 Cells
	IL-15RA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 46.92 kDa and the accession number is NP_002180.1.
TMPY-05741	IL-15RA Protein, Human, Recombinant (aa 31-205, hFc) interleukin 15 receptor, alpha,CD215	Human	HEK293 Cells
	IL-15RA Protein, Human, Recombinant (aa 31-205, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.22 kDa and the accession number is Q13261-1.
TMPY-06591	IL-15RA Protein, Mouse, Recombinant (aa 1-205, hFc) interleukin 15 receptor, alpha,interle...	Mouse	HEK293 Cells
	IL-15RA Protein, Mouse, Recombinant (aa 1-205, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.10 kDa and the accession number is Q60819-1.
TMPK-00160	IL-15RA Protein, Human, Recombinant (His & Avi), Biotinylated MGC104179,IL-15 R α,IL-15RA,IL-15...	Human	HEK293 Cells
	Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelial lymphocyte development. IL-15RA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.3 kDa and the accession number is Q13261-1.
TMPK-00159	IL-15RA Protein, Human, Recombinant (His & Avi) IL-15 R α,IL-15RA/IL-15 R α/CD2	Human	HEK293 Cells
	Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and intestinal intraepithelial lymphocyte development. IL-15RA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.3 kDa and the accession number is Q13261-1.
TMPY-00803	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) GFND,LETS,ED-B,fibronectin 1,CIG,GFND2,FNZ,FINC,FN,MSF	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPK-00084	IL-17C Protein, Human, Recombinant (His & Avi) IL-17C,Cytokine CX2,IL17C,CX2,IL-17CMGC126884	Human	HEK293 Cells
	Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold. IL‑17C is Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by sig...
TMPJ-00239	IL-2RG Protein, Mouse, Recombinant (aa 25-263, hFc) Il2rg,Interleukin 2 receptor, gamma chain, isoform ...	Mouse	HEK293 Cells
	The Interleukin-2 receptor gamma chain (IL-2 Rγ, CD132) of the high affinity functional mouse IL-2 receptor complex is a member the hematopoietin receptor family. It is expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. Common IL2 receptor-γ Chain is required for IL-2 receptor signaling. Besides IL-2, the Common IL2 receptor-γ chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15....
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His) Interferon γ-inducing factor,Interleukin-1 gamma,Ig...	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins...
TMPJ-01316	IL-21 Protein, Mouse, Recombinant (His) 白细胞介素,IL-21,Interleukin-21,白介素,IL21	Mouse	E. coli
	Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun...
TMPY-05562	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) fibronectin 1,ED-B,CIG,FNZ,MSF,FN,FINC,GFND,LETS,GFND2	Human	HEK293 Cells
	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,SARS-CoV-2 epitope	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) SARS-CoV-2 epitope,MHC	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

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